重组眼镜蛇蛇毒蛋白
| 英文名称 | Recombinant Chinese cobra Cytotoxin 1 protein, His |
| 中文名称 | 重组眼镜蛇蛇毒蛋白 |
| 别 名 | 3SA1_NAJAT; Cytotoxin 1 · Naja atra (Chinese cobra); Cytotoxin1; Recombinant Chinese cobra Cytotoxin 1 protein, His |
| 理论分子量 | 22.2kDa |
| 检测分子量 | 27 kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | ＞0.5 mg/ml |
| 物 种 | Cobra |
| 序 列 | 22-81/81 |
| 纯 度 | >95% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | E.coli |
| 活性 | Not tested |
| 标签 | His |
| 缓 冲 液 | 20 mM Tris-HCl (pH=8.0) with 0.25 mM NaCl |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity). It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165). It also binds with high affinity to heparin (PubMed:17685633). |
| 产品图片 |
 The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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