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Vorinostat
CAS No. : 149647-78-9
MCE 国际站：Vorinostat
产品活性：Vorinostat (SAHA) 是一种有效的，可口服的 HDAC1，HDAC2，HDAC3 (Class I)，HDAC6 和 HDAC7 (Class II) 和 Class IV (HDAC11) 的抑制剂，对 HDAC1/3 的 ID50 值分别为 10 nM 和 20 nM。Vorinostat 可以诱导细胞凋亡 (apoptosis)。Vorinostat 还是一种人类乳头瘤病毒 (HPV)-18 DNA 扩增的有效抑制剂。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Autophagy | Anti-infection | Apoptosis
作用靶点：HDAC | Autophagy | Mitophagy | Filovirus | Apoptosis | HPV
In Vitro: Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells.Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC25 values of 1 µM and 0.5 µM, respectively.Vorinostat is an effective inhibitor of HPV-18 DNA amplification, reduces oncoproteins E6 and E7 activities and triggers apoptosis in HPV-infected, differentiated cells.
In Vivo: Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×106 MES-SA cells.
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