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Sildenafil

CAS No. : 139755-83-2

MCE 国际站：Sildenafil

产品活性：Sildenafil (UK-92480) 是一种有效的磷酸二酯酶 5 (PDE5)抑制剂，IC₅₀ 为 5.22 nM。

研究领域：Metabolic Enzyme/Protease  |  Autophagy  |  Apoptosis  |  Anti-infection

作用靶点：Phosphodiesterase (PDE)  |  Autophagy  |  Apoptosis  |  Bacterial

In Vitro: Pretreatment with 1 μM Sildenafil potentiates the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P<0.05). Pretreatment with 1 μM Sildenafil citrate followed by serotonin stimulation leads to dramatic increase in OD value to 0.33, significantly different compared with serotonin stimulation alone (P<0.05). 1 μM Sildenafil obviously enhances the upregulation of ERK1/ERK2 phosphorylation induced by serotonin.

In Vivo: In the dog model of erection, Sildenafil citrate significantly increases ICP and ICP/BP but shows no significant effect on BP compared with vehicle. Sildenafil treatment significantly decreases the number of TL⁺-cells at 10 but not 0.5 mg/kg. 8 days after pMCAo the number of microglia/macrophages stained by Iba-1 are significantly reduced by Sildenafil treatment (0.5 and/or 10 mg/kg dose). Sildenafil citrate has been reported to decrease flap necrosis in preclinical animal models by increasing the secretion of growth factors (FGF and VEGF), and histologically is shown to be effective in rat cavernous nerve architecture.

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