FITC标记的NK细胞受体BY55抗体
产品名称： FITC标记的NK细胞受体BY55抗体
英文名称： Anti-CD160/FITC
产品编号： HZ-2526R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CD160/FITC Conjugated antibody
FITC标记的NK细胞受体BY55抗体
| 英文名称 | Anti-CD160/FITC |
| 中文名称 | FITC标记的NK细胞受体BY55抗体 |
| 别 名 | By55; Natural killer cell receptor BY55; BY55; CD160 antigen [Precursor]; CD160 molecule; FLJ46513; Natural killer cell receptor BY55; NK1; NK28; BY55_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 自然杀伤细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14.7kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD160 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] Function: Receptor showing broad specificity for both classical and non-classical MHC class I molecules. Subunit: Homomultimer; disulfide-linked. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 11126 Human Omim: 604463 Human SwissProt: O95971 Human Unigene: 488237 Human Unigene: 740780 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CD160是一种27 kDa糖蛋白，最初用单克隆抗体BY55鉴定。其表达与外周血NK细胞和CD8T淋巴细胞密切相关，具有杀伤效应。CD160的cDNA序列预测含有181个氨基酸的富含半胱氨酸的糖基磷脂酰肌醇锚定蛋白，其单个Ig样结构域与KIr2DL4分子弱同源。CD160在细胞表面表达为紧密二硫键连接的多聚体。RNA印迹分析显示CD160 mRNA为1.5和1.6 kb，其表达高度限制于循环NK细胞和T细胞、脾和小肠。在NK细胞中CD160由CD56DimCD16+细胞表达，而在循环T细胞中，其表达主要限于TCRGD承载细胞和TcRab+CD8BryCD95+CD56+CD23-CD27细胞。在组织中，CD160在所有肠上皮内淋巴细胞表达。CD160显示出与经典和非经典MHC I类分子结合的广泛特异性。[ RefSeq，JUL 2008 ]