FITC标记的锌指RNA结合蛋白抗体
产品名称： FITC标记的锌指RNA结合蛋白抗体
英文名称： Anti-ZFR/FITC
产品编号： HZ-19137R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZFR/FITC Conjugated antibody
FITC标记的锌指RNA结合蛋白抗体
| 英文名称 | Anti-ZFR/FITC |
| 中文名称 | FITC标记的锌指RNA结合蛋白抗体 |
| 别 名 | FLJ41312; hZFR; M phase phosphoprotein homolog; M-phase phosphoprotein homolog; zfr; ZFR_HUMAN; zinc finger RNA binding protein; Zinc finger RNA-binding protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞凋亡 转录调节因子 结合蛋白 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZFR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ZFR is 1,074 amino acid RNA-binding protein. In human, ZFR is expressed in lung, liver, lymphocytes, heart, pancreas, kidney and placenta, and regulates postimplantation and gastrulation stages of development. Murine ZFR is observed in testis, ovary and brain. With elevated levels of expression during meiosis, ZFR associates with chromosome foci in meiotic cells. ZFR contains 1 DZF domain and localizes in the somatodendritic compartment of hippocampal neurons and colocalizes with STAU2 in cytosolic RNA granules. Knockout of ZFR in mouse embryo prevents the development of some embryonic structures leads to an increase in programmed cell death with a decrease in mitotic index. Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA. Subcellular Location: Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules. Tissue Specificity: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney. Similarity: Contains 1 DZF domain. Database links: Entrez Gene: 51663 Human Entrez Gene: 22763 Mouse Entrez Gene: 365703 Rat Entrez Gene: 321659 Zebrafish SwissProt: Q96KR1 Human SwissProt: O88532 Mouse SwissProt: Q562A2 Rat SwissProt: Q6PCR6 Zebrafish Unigene: 435231 Human Unigene: 273496 Mouse Unigene: 11634 Rat Unigene: 26724 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ZFR是1074个氨基酸的RNA结合蛋白。在人类中，ZFR在肺、肝脏、淋巴细胞、心脏、胰腺、肾脏和胎盘中表达，并调节着植入后和胚胎发育阶段。Murine ZFR在睾丸、卵巢和脑中均有观察。减数分裂过程中表达水平升高，ZFR与减数分裂细胞中的染色体焦点相关。ZFR含有1个DZF结构域，定位于海马神经元的体树突室中，并在胞浆RNA颗粒中与STAU2共存。在小鼠胚胎中敲除ZFR可阻止某些胚胎结构的发育，导致程序性细胞死亡增加，有丝分裂指数降低。