FITC标记的睫状神经营养因子受体α抗体
产品名称： FITC标记的睫状神经营养因子受体α抗体
英文名称： Anti-CNTF Receptor alpha/FITC
产品编号： HZ-1516R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CNTF Receptor alpha/FITC Conjugated antibody
FITC标记的睫状神经营养因子受体α抗体
| 英文名称 | Anti-CNTF Receptor alpha/FITC |
| 中文名称 | FITC标记的睫状神经营养因子受体α抗体 |
| 别 名 | CNTFR Alpha; Ciliary neurotrophic factor receptor alpha; CNTFR Alpha; CNTFR; Ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR Alpha; CNTFR; CNTFR-alpha; CNTFR. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CNTFR Alpha |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]. Function: Binds to CNTF. The alpha subunit provides the receptor specificity. Subunit: Heterotrimer of the alpha subunit, LIFR and IL6ST. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Nervous system and skeletal muscle. Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Database links: Entrez Gene: 442941 Dog Entrez Gene: 1271 Human Entrez Gene: 12804 Mouse Entrez Gene: 313173 Rat Omim: 118946 Human SwissProt: Q71DR4 Dog SwissProt: P26992 Human SwissProt: O88507 Mouse SwissProt: Q08406 Rat Unigene: 129966 Human Unigene: 425178 Mouse Unigene: 55036 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） CNTFRα是CNTF的特异性结合蛋白。在周围神经损伤后CNTF与其受体有其特异的变化模式及调节机制，对神经损伤后的再生有重要作用 |
该基因编码1型细胞因子受体家族的成员。其编码的蛋白质为睫状神经营养因子受体配体的三方具体的组成部分，起着至关重要的作用在神经细胞的存活、分化及基因表达。睫状神经营养因子的基因编码的蛋白结合新兵的受体的跨膜组件，gp130和白血病抑制因子受体信号转导，促进。在这个基因的单核苷酸多态性可能与肌肉力量的变化有关，以及进食障碍发病早期。另外，已经观察到该基因的剪接转录变体。[ RefSeq，2011年5月提供]。