TNNI3 polyclonal antibody
产品名称： TNNI3 polyclonal antibody
英文名称： TNNI3 polyclonal antibody
产品编号： PAB17292
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TNNI3.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding serine 363 of human TNNI3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody detects endogenous levels of total TNNI3 protein.
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- An R111C polymorphism in wild turkey cardiac troponin I accompanying the dilated cardiomyopathy-related abnormal splicing variant of cardiac troponin T with potentially compensatory effects.
Biesiadecki BJ, Schneider KL, Yu ZB, Chong SM, Jin JP.J Biol Chem. 2004 Apr 2;279(14):13825-32. Epub 2004 Jan 20.
- 2.
- Circulating cardiac troponin I in severe congestive heart failure.
Missov E, Calzolari C, Pau B.Circulation. 1997 Nov 4;96(9):2953-8.
- Entrez GeneID:
- 7137
- Protein Accession#:
- P19429
- Gene Name:
- TNNI3
- Gene Alias:
- CMD2A,CMH7,MGC116817,RCM1,TNNC1,cTnI
- Gene Description:
- troponin I type 3 (cardiac)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq
- Other Designations:
- familial hypertrophic cardiomyopathy 7,troponin I, cardiac
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Cardiomegaly
- Cardiomyopathy, Dilated
- Cardiomyopathy, Hypertrophic
- Cardiomyopathy, Hypertrophic, Familial
- Cardiomyopathy, Restrictive
- Cardiovascular Diseases
- Death, Sudden, Cardiac
- Diabetes Complications
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Hypertrophy, Left Ventricular
- Lipid Metabolism, Inborn Errors
- Metabolic Syndrome X
- Mitochondrial Myopathies
- Neoplasms
- Osteoporosis
- Tachycardia, Ventricular