CDK9 (C-term) Peptide
产品名称： CDK9 (C-term) Peptide
英文名称： CDK9 (C-term) Peptide
产品编号： P2530
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDK9.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDK9.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA,Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
- 2.
- Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.
Fu TJ, Peng J, Lee G, Price DH, Flores O.J Biol Chem. 1999 Dec 3;274(49):34527-30.
- 3.
- Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.
Best JL, Presky DH, Swerlick RA, Burns DK, Chu W.Biochem Biophys Res Commun. 1995 Mar 17;208(2):562-8.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDK9 polyclonal antibody (Cat # PAB2919) in HepG2 (left) , Jurkat (middle) , and 294 (right) cell line lysates. CDK9 (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with CDK9 polyclonal antibody (Cat # PAB2919) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 1025
- Protein Accession#:
- NP_001252;P50750
- Gene Name:
- CDK9
- Gene Alias:
- C-2k,CDC2L4,CTK1,PITALRE,TAK
- Gene Description:
- cyclin-dependent kinase 9
- Omim ID:
- 603251
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq
- Other Designations:
- CDC2-related kinase,OTTHUMP00000022198,cell division protein kinase 9,serine/threonine protein kinase PITALRE