CARD8 (Human) Recombinant Protein (Q01)
产品名称： CARD8 (Human) Recombinant Protein (Q01)
英文名称： CARD8 (Human) Recombinant Protein (Q01)
产品编号： H00022900-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human CARD8 partial ORF ( NP_055774, 322 a.a. - 431 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- WDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 22900
- GeneBank Accession#:
- NM_014959
- Protein Accession#:
- NP_055774
- Gene Name:
- CARD8
- Gene Alias:
- CARDINAL,DACAR,DKFZp779L0366,Dakar,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP,NDPP1,TUCAN
- Gene Description:
- caspase recruitment domain family, member 8
- Omim ID:
- 609051
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq
- Other Designations:
- CARD inhibitor of NF-kappaB-activating ligands,CARD8 isoform T47,CARD8 isoform T51,CARD8 isoform T60,apoptotic protein NDPP1,tumor up-regulated CARD-containing antagonist of caspase nine
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Arthritis
- Arthritis, Rheumatoid
- Bacterial Infections
- Colitis, Ulcerative
- Colorectal Neoplasms
- Crohn Disease
- Crohn's disease
- Disease Progression
- Encephalitis
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Inflammatory Bowel Diseases
- Tobacco Use Disorder