FITC标记的锌指蛋白259抗体
产品名称： FITC标记的锌指蛋白259抗体
英文名称： Anti-ZNF259/ZPR1/FITC
产品编号： HZ-18505R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF259/ZPR1/FITC Conjugated antibody
FITC标记的锌指蛋白259抗体
| 英文名称 | Anti-ZNF259/ZPR1/FITC |
| 中文名称 | FITC标记的锌指蛋白259抗体 |
| 别 名 | MGC110983; Zinc finger protein 259; Zinc finger protein ZPR1; ZNF 259; ZNF259; ZPR1; ZPR1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF259/ZPR1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ZPR1 is a zinc finger-containing protein that is capable of binding to the intracellular tyrosine kinase domain of the epidermal growth factor receptor. Stimulation of mammalian cells with epidermal growth factor reduces ZPR1 affinity for the EGFR and leads to an accumulation of the protein in the nucleus. The ZPR1 zinc finger is necessary for its association with the EGFR. Function: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O(2)-induced neuronal cell death. Subunit: Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum By similarity. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor. Subcellular Location: Cytoplasm. Nucleus > nucleolus. Translocates to the nucleolus after treatment with mitogens. Tissue Specificity: Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebellum. DISEASE: May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration (Ref.7). Disruption phenotype Die during early embryonic development. Embryos show growth delay, failed to form normal trophectoderm and to expand the inner cell mass. Similarity: Belongs to the ZPR1 family. Database links: Entrez Gene: 8882 Human Entrez Gene: 22687 Mouse Entrez Gene: 500989 Rat Omim: 603901 Human SwissProt: O75312 Human SwissProt: Q62384 Mouse Unigene: 7165 Human Unigene: 17519 Mouse Unigene: 102011 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
ZPR1是一种含锌指的蛋白质，能够与表皮生长因子受体的细胞内酪氨酸激酶结构域结合。用表皮生长因子刺激哺乳动物细胞可降低ZPR1对EGFR的亲和力，并导致蛋白质在细胞核中的积累。ZPR1锌指与EGFR的关系是必需的。