ZIC3 polyclonal antibody
产品名称： ZIC3 polyclonal antibody
英文名称： ZIC3 polyclonal antibody
产品编号： PAB1954
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ZIC3.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ZIC3.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Characterization of the interactions of human ZIC3 mutants with GLI3.
Zhu L, Zhou G, Poole S, Belmont JW.Hum Mutat. 2008 Jan;29(1):99-105.
- 2.
- Identification of a novel role of ZIC3 in regulating cardiac development.
Zhu L, Harutyunyan KG, Peng JL, Wang J, Schwartz RJ, Belmont JW.Hum Mol Genet. 2007 Jul 15;16(14):1649-60. Epub 2007 Apr 27.
- 3.
- Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3.
Bedard JE, Purnell JD, Ware SM.Hum Mol Genet. 2007 Jan 15;16(2):187-98. Epub 2006 Dec 21.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ZIC3 polyclonal antibody (Cat # PAB1954) in HL-60 cell line lysates (35 ug/lane).ZIC3 (arrow) was detected using the purified polyclonal antibody (1 : 60dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ZIC3 polyclonal antibody (Cat # PAB1954), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 7547
- Protein Accession#:
- NP_003404;O60481
- Gene Name:
- ZIC3
- Gene Alias:
- HTX,HTX1,ZNF203
- Gene Description:
- Zic family member 3 (odd-paired homolog, Drosophila)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq
- Other Designations:
- OTTHUMP00000024142,heterotaxy 1,zinc finger protein of the cerebellum 3
- Related Disease